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To avoid bacterial resistance I reserve antibiotics for moderate cases.</p> <p>The treatment for GBS is antibiotics in the event the membranes rupture or labor starts, which ever comes first. The first option is penicillin, but ampicillin, a closely related drug, may also be used. Women with mild allergies to penicillin normally can receive a drug called cefazolin (also known as Ancef). Options for women with a serious penicillin allergy include clindamycin and erythromycin; however, these drugs don't always work therefore the lab needs to perform special testing to ascertain if these antibiotics can kill the strain of GBS that's present (this is whats called susceptibility testing). Penicillin, ampicillin, and cefazolin always " cure " GBS so testing isn't necessary. 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