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Clinical studies on pyridoxine in relation to neurological effects (see Table 2 for particular person/anecdotal proof) Duration Dosage Authors Subjects Number of Findings Conclusions (mg/day) therapy No modifications in distal Patients with motor Duration too Del Tredici et al carpal tunnel 24 a hundred and fifty or 300 four months latency or short to assess (1985) syndrome self-assesneurological results sment questionnaire the condition could also be as a result of pyridoxine defiEllis et al Patients with No opposed ciency; typical therapy (1979) (and carpal tunnel 35 100-300 as much as 12 neurologischedule of 12 weeks research cited); syndrome weeks cal effects (Ellis, 1987) is of too brief Ellis (1987) reported duration to access neurological results Patients with No assessDuration too Kerr (1977) premenstrual 70 forty-100 2 months ment of side short to evaluate syndrome results neurological effects No neurological comSmall group dimension but plications in very prolonged length; Patients with 22 sufferers infiuence of the or nerve Mitwalli et al hyperoxaluria 22 250-500 1-6 years conduction illness on (1984) (kidney abnormapyridoxine dealing with, stones) necessities and lities in 7 sufferers neurological response usually are not recognized studied in detail Small group size but very No abnorextended length; the malities of absence of results at Patients with motor or doses equal to 10-90 Mpofu et al homocystei17 200-500 10-24 years sensory mg/kg/day means that (1991) nuria nerve these patients could show conduction reduced responsiveness velocities to the neuronal antagonistic effects of pyridoxine Pauling (1984) Undefined >5000 200 not given No details No details obtainable; cites Hawkins patients can't be assessed No assesResults from a survey Pullon et al Women 410 not described not described sments of of 1826 girls; no (1989) possible information on tolerability neuropathy and side effects No results Small number of topics and really restricted Tolis et al Women 9 200 or 400 2 months on progress period of therapy; (1977) hormone or no evaluation of prolactin neurological effects No distinction in Women with unwanted side effects Duration too Williams et al premenstrual 204 (out one hundred 3 months between quick to entry (1985) syndrome of 434) treatments neurological results and placebo teams Data evaluation for A systematic review of printed and Women with stories of unpublished Wyatt et al premenstrual 526 (out 50-600 as much as 4 unwanted side effects; randomised (1999) syndrome of 910) months 1 reported placebo controlled case of trials; all research of neurological insufficient period side effects 37 europa. 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